IKK/NF-κB signaling: balancing life and death – a new approach to cancer therapy

By Jun-Li Luo, H. Kamata, M. Karin. 2005

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Integrating cell-signalling pathways with NF-κB and IKK function (2007, background): “Activation of IKKβ stimulates anti-apoptotic, pro-inflammatory and proliferative pathway”
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. (2009, background): “NFjB is known to activate several target genes which are required for the tumor growth [54] and references therein.”
An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation (2009, neutral): “Activation of the NF-kB pathway is correlated with carcinogenesis ( Luo et al., 2005 ), Let-7 is downregulated in several cancers (Johnson et al., 2005; Mayr et al., 2007; Sampson et al., 2007), Lin28 is overexpressed in primary human tumors (Viswanathan et al., 2009)(Figure 7D),and IL6has been impl”
Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009, background): “One of the most documented functions of NF-κB is its ability to promote cell survival through the induction of target genes, the products of which inhibit the apoptotic machinery in both normal and malignant cell”