Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.

By Y. Fukata, Kozo Kaibuchi, M. Amano. TIPS - Trends in Pharmacological Sciences, 2001

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Rac and Rho GTPases in cancer cell motility control (2010, background): “Totsukawa G, Yamakita Y, Yamashiro S, Hartshorne DJ, Sasaki Y, Matsumura F: Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.”
Functional diversity of protein phosphatase-1, a cellular economizer and reset button. (2004, background): “For instance, Rho-activated Rho-kinase phosphorylates myosin in central stress fibers, whereas Ca 2ϩ /calmodulin-activated MLCK or Cdc42-activated MRCK act on peripheral stress fibers (112, 197, 366).”
Prespecification and plasticity: shifting mechanisms of cell migration. (2004, neutral): “myosin-II-mediated actin filament stabilization and contraction [28,59].”
Adhesion-dependent cell mechanosensitivity. (2003, background): “ROCK is known to activate myosin II (Fukata et al. 2001, Kimura et al. 1996); our experiments revealed that the function of ROCK in focal adhesion formation is primarily associated with the activation of myosin II-driven contractility (Riveline et al. 2001).”