Metals, toxicity and oxidative stress.

By M. Valko, H. Morris, M. Cronin. Current Medicinal Chemistry, 2005

4,879 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/327c859bd86d573bfae1efd34389a59fcb034338

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. K. Krishnan
2. Inna M. Sokolova
3. K. Jomová
4. V. Lushchak
5. C. Brauner
6. A. Farrell
7. M. Valko
8. C. Wood

In Nutrition and Dietetics

1. K. Krishnan
2. K. Jomová
3. V. Lushchak
4. M. Valko
5. Zhushan Fu
6. Shuhua Xi
7. Chunyan Guo
8. R. Dubey

Citations in the corpus

• Homeostasis and toxicology of essential metals (2012, background): “Evidence of induction of oxidative stress by metal exposure abounds in the mammalian literature (see Ercal et al., 2001, and Valko et al., 2005, for reviews).”
• Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “…of carcinogenesis and ageing Leonard et al., 2004; Pourahmad & O’Brien, 2001; Roy Saha, 2002; Santos et al., 2005; Stayner, Dankovic, & emen, 1996; Valko et al., 2005; Waalkes, Liu, Ward, & iwan, 2004). hemistry & Cell Biology 39 (2007) 44–84 59 Iron-induced oxidative stress is considered to be…”
• Metals as a cause of oxidative stress in fish: a review. (2018, background): “Chromium (III), meanwhile, is not able to use this mechanism (Valko et al., 2005).”
• Environmentally induced oxidative stress in aquatic animals. (2011, background): “The inorganic arsenics can be either methylated (monomethylarsonic acid, MMA), or dimethylated (dimethylarsinic acid—DMA) in vivo (Valko et al., 2005).”
• Alleviation of temperature stress by nutrient management in crop plants: a review (2012, background): “Selenium deficiency is usually associated with increased lipid peroxidation which alters the integrity of cell membranes and consequently, affects cell functions (Stadtman, 1990; Valko et al., 2005).”
• Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “Damage to proteins caused by different metals mainly involves loss of histidine residues, carbonyl group attachment and bityrosine cross links in addition to generation of carbon centered alkyl radical (R‚), alkoxyl (RO‚) and peroxyl (ROO‚) radicals [139].”
• Interactive effects of metal pollution and temperature on metabolism in aquatic ectotherms: implications of global climate change (2008, background): “…different metals may vary, many metals have common toxic cellular mechanisms and elicit similar protective responses in a wide variety of organisms (reviewed by Byczkowski & Sorenson 1984, Roesijadi & Robinson 1994, Wallace & Starkov 2000, Coyle et al. 2002, Valko et al. 2005, Amiard et al. 2006).”
• Energy homeostasis as an integrative tool for assessing limits of environmental stress tolerance in aquatic invertebrates. (2012, background): “…stress, UV radiation, metals and xenobiotics induce elevated ROS generation above the normal background levels and thus require energy-costly upregulation of antioxidant defenses (Winston and Giulio, 1991; Valko et al., 2005; Bertin and Averbeck, 2006; Abele et al., 2007; Kakkar and Singh, 2007).”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “H2O2 can generate hydroxyl radicals (OH) via a Fenton reaction [46].”
• Interactions between effects of environmental chemicals and natural stressors: a review. (2010, background): “These changes in membrane phospholipids can probably be explained by copper's ability to induce lipid peroxidation, where especially phospholipids containing two or more double bonds are particularly susceptible to oxidation by free radicals and other highly reactive species (Valko et al., 2005).”