Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases.
By Shokei Kim, H. Iwao. Pharmacological Reviews, 2000
1,036 citations recorded by the source corpus.
A growing body of evidence supports the notion that angiotensin II (Ang II), the central product of the renin-angiotensin system, may play a central role not only in the etiology of hypertension but also in the pathophysiology of cardiovascular and renal diseases in humans. In this review, we focus on the role of Ang II in cardiovascular and renal diseases at the molecular and cellular levels and discuss up-to-date evidence concerning the in vitro and in vivo actions of Ang II and the pharmacological effects of angiotensin receptor antagonists in comparison with angiotensin-converting enzyme inhibitors. Ang II, via AT(1) receptor, directly causes cellular phenotypic changes and cell growth, regulates the gene expression of various bioactive substances (vasoactive hormones, growth factors, extracellular matrix components, cytokines, etc.), and activates multiple intracellular signaling cascades (mitogen-activated protein kinase cascades, tyrosine kinases, various transcription factors, etc.) in cardiac myocytes and fibroblasts, vascular endothelial and smooth muscle cells, and renal mesangial cells. These actions are supposed to participate in the pathophysiology of cardiac hypertrophy and remodeling, heart failure, vascular thickening, atherosclerosis, and glomerulosclerosis. Furthermore, in vivo recent evidence suggest that the activation of mitogen-activated protein kinases and activator protein-1 by Ang II may play the key role in cardiovascular and renal diseases. However, there are still unresolved questions and controversies on the mechanism of Ang II-mediated cardiovascular and renal diseases.
Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Pharmacology
View Paper: https://www.semanticscholar.org/paper/326a690cee20c96508df529f86cdff13551b7748
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In Cardiology and Cardiovascular Medicine
In Endocrinology, Diabetes and Metabolism
Citations in the corpus
- Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. (2010, background): “Angiotensin II was also found to enhance inflammation and the development of atherosclerosis (Kim and Iwao, 2000).”
- Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. (2005, background): “Ang II is known to possess potent vasocontrictive activity, which increases peripheral resistance to blood flow and raises blood pressure (3, 14).”
- The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease (2007, background): “The molecular mechanisms responsible for Ang II-induced cell injury have been reviewed by Kim and Iwao (2000) and Touyz and Schiffrin (2000) and will not be discussed in detail in this review.”
- Angiotensin II revisited: new roles in inflammation, immunology and aging (2010, background): “…increasing blood flow in the kidney (Hamilton et al, 2001) and brain (Kramar et al, 1997). www.embomolmed.org EMBO Mol Med 2, 247–257 Circulating Ang II contributes to increased blood pressure and influences renal tubuli to retain sodium and water (Brewster & Perazella, 2004; Kim & Hiroshi, 2003).”