Differential Effects of Culture on Imprinted H19 Expression in the Preimplantation Mouse Embryo1

By A. S. Doherty, M. Mann, K. Tremblay, M. Bartolomei, R. Schultz. Biology of Reproduction, 2000

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Culture of Preimplantation Mouse Embryos Affects Fetal Development and the Expression of Imprinted Genes1 (2001, background): “In a recent study on the preimplantation stage of mouse development, Doherty and coworkers reported that culture of two-cell embryos to blastocysts in Whitten’s medium (to which no serum was added) can lead to a loss of (paternal) methylation (and gain of expression) at the H19 gene [52].”
Persistent epigenetic differences associated with prenatal exposure to famine in humans (2008, background): “Experiments in which mouse zygotes were cultured to blastocysts favor this hypothesis (6, 7).”
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. (2003, background): “…(M16) undergo epigenetic alterations in the H19, IGF2, Grb10, and Grb7 genes (Khosla et al. 2001); mouse embryos cultured in Whitten’s medium can undergo LOI of H19 (Doherty et al. 2000); and cloned mice show variations in several imprinted genes in the resulting embryos (Humpherys et al. 2001).”
Board-invited review: intrauterine growth retardation: implications for the animal sciences. (2006, neutral): “Interestingly, Igf2 is paternally expressed and maternally silent, whereas H19 is paternally silent and preferentially expressed from the maternal allele (Doherty et al., 2000).”