DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

By J. Millar, B. Pickard, Shaun Mackie, R. James, S. Christie, S. R. Buchanan, M. Malloy, Jennifer E. Chubb, E. Huston, G. Baillie and 10 more. Science, 2005

685 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3250b20ffb7cfcdfb24d5650b73ab6b8efac710b

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In Molecular Biology

1. Trevor W. Robbins
2. A. Arnsten
3. J. Beavo

Citations in the corpus

• Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use (2006, background): “An example suggesting the physiological importance of PDE4 localization is the recent report of the association of PDE4B and the protein for the disrupted in schizophrenia 1 (DISC1) gene (Millar et al., 2005).”
• Stress signalling pathways that impair prefrontal cortex structure and function (2009, neutral): “For example, disrupted in schizophrenia 1 ( DISC1 ) normally provides negative feedback on cAMP signalling, but a mutation in DISC1 decreased the activity of the phosphodiesterase PDE4B in the presence of high concentrations of cAM”
• The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation (2009, background): “DISC1 normally interacts with phosphodiesterase 4B (PDE4B) to increase the hydrolysis of cAMP under conditions of high cAMP concentrations (Millar et al. 2005, 2007).”