Anomalous subdiffusion is a measure for cytoplasmic crowding in living cells.

By M. Weiss, Markus Elsner, F. Kartberg, T. Nilsson. Biophysical Journal, 2004

729 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/323e671d9effe6bd8fa230d746d01b18216372ef

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In Atomic and Molecular Physics, and Optics

In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Anomalous diffusion of proteins due to molecular crowding. (2005, background): “Indeed, it was shown that anomalous diffusion of dextrans in cell did not disappear after depolymerization of the microtubule network (27).”
Subdiffraction-limited quantum imaging within a living cell (2013, neutral): “2(a)] that suggest a spatial gradient in the molecular crowding along the x axis [37], along with narrow dips in α”
Anomalous transport in the crowded world of biological cells (2013, methodology): “Intracellular membranes were addressed by Weiss et al [293], who monitored three Golgi-resident enzymes both in the endoplasmic reticulum and in the Golgi apparatus of HeLa cells.”
Quantum metrology and its application in biology (2014, background): “The cellular cytoplasm is crowded with large molecules, polymer networks, and various other organelles which confine the particle and influence the thermal motion [155].”
Stochastic models of intracellular transport (2013, background): “…consequence of molecular crowding is that it hinders diffusion, although there is an ongoing debate regarding to what extent this results in anomalous diffusion rather than a simple reduction in the normal diffusion coefficient (Banks and Fradin, 2005; Dix and Verkman, 2008; Weiss et al., 2004).”
Particle tracking in living cells: a review of the mean square displacement method and beyond (2013, neutral): “Another comparison is available for HeLa cells, where the tracking method was the same, yet the probe particles had different chemistry (Guigas et al. 2007; Weiss et al. 2004).”
Inaugural Article: Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function (2010, neutral): “One could also further analyze the periods of anomalous subdiffusive movement (sublinear time-lag dependence of the MSD) to understand the finer details of the cellular environment (54, 55).”
Diffusion, Crowding & Protein Stability in a Dynamic Molecular Model of the Bacterial Cytoplasm (2010, background): “This is because the timescales over which the two types of experiments are conducted are quite different: translational diffusion coefficients are obtained from FCS experiments by fitting to an autocorrelation function over a timescale extending from microseconds to seconds [21,22,66] while rotation”