Catabolite activator protein: DNA binding and transcription activation.
By Catherine L. Lawson, David Swigon, K. Murakami, S. Darst, Helen M. Berman, R. Ebright. 2004
328 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
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In Genetics
In Molecular Biology
- Catherine L. Lawson
- G. Ponce-Soto
- Helen M. Berman
- J. Quispe
- R. Sauer
- Adam J. Rubin
- Joseph H. Davis
- R. Ebright
Citations in the corpus
- Visualization of two architectures in class-II CAP-dependent transcription activation (2019, methodology): “of RNAP holoenzyme and initiates transcription via a recruitment and isomerization mechanism [4,11-14].”
- Origins of specificity in protein-DNA recognition (2010, neutral): “The DNA-binding site of the catabolite activator protein (CAP) shows dramatic kinks at two CpA (TpG) steps (16, 169), which cause, along with two additional smaller kinks, an”
- Three-dimensional EM structure of an intact activator-dependent transcription initiation complex (2009, background): “At Class I CAP-dependent promoters, CAP activates transcription by making protein-protein interactions with the RNAP subunit C-terminal domain ( CTD), a 9-kDa independently folded domain that is flexibly tethered to the remainder of RNAP (1, 2, 7, 8).”
- Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein (2013, neutral): “biochemical, genetic and biophysical experiments [2,5,13,14,16]”
- Design, construction and characterization of a set of insulated bacterial promoters (2010, background): “For example, cyclic-AMP receptor protein (CRP) binds the promoter upstream of the 35 box, simultaneously making favorable contacts with the C-terminal domain of the polymerase a subunits (24,25).”
- The Transcriptional Regulators of the CRP Family Regulate Different Essential Bacterial Functions and Can Be Inherited Vertically and Horizontally (2017, background): “At this type of promoters, CRP also recruits the RNA-P through the interaction with the α-CTD to form the closed complex and facilitates isomerization of the RNA-P into the open complex (Lawson et al., 2004).”