Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

By T. T. Lam, Na Jia, Yawei Zhang, Marcus H. Shum, Jia-Fu Jiang, H. Zhu, Y. Tong, Yongxia Shi, Xue-bing Ni, Yunshi Liao and 19 more. Nature, 2020

1,644 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/31dba4043bcc9970c27145e32cd4e728ee6f22f9

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Citations in the corpus

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding (2020, neutral): “The SARS-CoV-1-related bat strain LYRa11 binds with even lower affinity, while the more distant bat RBDs (HKU3-1 and BM48-31) have no detectable binding.”
A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein (2020, positive): “Such an evolutionary pattern is indicative of a complex combination of recombination and natural selection [6, 15].”
Within the Lack of Chest COVID-19 X-ray Dataset: A Novel Detection Model Based on GAN and Deep Transfer Learning (2020, background): “In 2019, Wuhan is a commercial center of Hubei province in China that faced a ﬂare-up of a novel 2019 coronavirus that killed more than hundreds and infected over thousands of individuals within the initial days of the novel coronavirus pestilence.”
Title: Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice (2020, neutral): “We also included RBDs from the GX pangolin clade 1/2 coronavirus (referred to here as pang17) (39), RaTG13, the bat clade 1/2 virus most closely related to SARS-CoV-2 (40), RmYN02, a clade 2 bat virus from China (41), and BtKY72, a Kenyan bat clade 3 virus (42).”
Coronavirus (COVID-19) (2020, background): “China; speculation is that pangolins may have been an intermediate species between bats and man [22, 23].”
Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir (2020, background): “SARS-CoV-2 is closely related to severe acute respiratory syndrome coronavirus (SARS-CoV) and several members from the beta coronavirus family, including bat and pangolin coronaviruses(3-5).”
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (2020, neutral): “The virus closest in sequence to SARS-CoV-2 observed to date was isolated from a bat (Zhou et al., 2020b), although the most proximal animal reservoir for SARS-CoV-2 remains unknown (Andersen et al., 2020; Lam et al., 2020).”
On the origin and continuing evolution of SARS-CoV-2 (2020, neutral): “remains unclear [5,13], several studies have shown that pangolins may have provided a partial spike gene to SARS-CoV-2; the critical functional sites in the spike protein of SARS-CoV-2 are nearly identical to those identified in a virus isolated from a pangolin [16–18].”
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells (2020, positive): “However, it is noteworthy that all SARS-CoV-2-related coronaviruses of bats and pangolins identified today harbor a monobasic cleavage site (Lam et al., 2020; Li et al., 2020; Zhang et al., 2020).”
A Review of SARS-CoV-2 and the Ongoing Clinical Trials (2020, background): “The primary Wuhan study revealed that upon diagnosis, 74 [75”