Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies

By D. McAllister, Ping M. Wang, Shawn P. Davis, Jung-Hwan Park, P. Canatella, Mark G. Allen, Mark R. Prausnitz. Proceedings of the National Academy of Sciences of the United States of America, 2003

845 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/31c7d1b3b0f6252186de51058ccdebcbaee8e420

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Citations in the corpus

Microneedles: A New Frontier in Nanomedicine Delivery (2016, neutral): “ability of solidMN arrays to enhance transdermal permeation of different molecules such as insulin (75), calcein (74,75), naltrexone (76) or proteins (75).”
Dissolving microneedles for transdermal drug delivery. (2008, background): “Previous studies have also pretreated skin by piercing it with microneedles and then applying a topical formulation or patch to deliver drug through the permeabilized skin [6,25].”
Microneedle technologies for (trans)dermal drug and vaccine delivery. (2012, methodology): “Another disadvantage of dissolving is the limited drug loading, e.g., bovine serum albumin (BSA) and calcein encapsulated polymeric microneedles have been made, however, a drug loading of more than 10% led to insufficient mechanical strength of the microneedles [34].”
Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin. (2017, methodology): “Laser cutting has also been used to make microneedles (73).”
Current status and future potential of transdermal drug delivery (2004, background): “In vitro experiments have shown that inserting MICRONEEDLES into skin can increase permeability by orders of magnitude for small drugs, large macromolecules and nanoparticle”
Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety (2010, background): “MN application has the potential to overcome the problems associated with delivery of small hydrophilic molecules, macromolecules, and biopharmaceuticals across biological barriers, particularly the SC.”
Microneedles for drug and vaccine delivery (2012, background): “The first studies of biotherapeutic delivery using microneedles employed silicon or glass microneedles for insulin delivery [38, 142], which demonstrated drops in blood-glucose levels after microneedle injection.”
Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum (2015, background): “by twisting of the skin fibers around the needles during application, particularly in the case of blunt and short MN [117].”
Coated microneedles for transdermal delivery. (2007, background): “In vitro skin permeability enhancement of two to four orders of magnitude was observed for small molecules like calcein and large compounds like proteins and nanoparticles [11,12].”
Hollow metal microneedles for insulin delivery to diabetic rats (2005, methodology): “Although not done in this study, microneedles can also be used in a manner more like an injection, where a drug solution is actively flowed through the needles and into the skin [ 17 ].”