Hollow metal microneedles for insulin delivery to diabetic rats

By Shawn P. Davis, Wijaya Martanto, Mark G. Allen, Mark R. Prausnitz. IEEE Transactions on Biomedical Engineering, 2005

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Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety (2010, positive): “…etching, injection moulding, reactive ion etching, surface/bulk micromachining, polysilicon micromoulding, lithography-electroforming-replication, and laser drilling (Trichur et al., 2002; Yang & Zahn, 2004; Davis et al., 2005; Moon et al., 2005; Park et al., 2005; Stoeber & Liepmann, 2005).”
Microneedle technologies for (trans)dermal drug and vaccine delivery. (2012, methodology): “silicon needles is that they may break and stay behind in the skin due to the fragile nature of silicon [28-35].”
Microneedles for drug and vaccine delivery (2012, methodology): “Hollow microneedle fabrication methods—Hollow microneedles have been fabricated directly from a material substrate using microelectromechanical systems (MEMS) techniques including laser micromachining [63], deep reactive ion etching of silicon [141– 142], an integrated lithographic molding technique”
Microneedles: A New Frontier in Nanomedicine Delivery (2016, positive): “Hollow MNs have been extensively used to deliver insulin (94,96,99).”