Bi-directional interconversion of brite and white adipocytes

By Matthias Rosenwald, Aliki Perdikari, T. Rülicke, C. Wolfrum. Nature Cell Biology, 2013

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Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “Beige adipocytes formed by cold stimulation revert to typical white adipocytes after warm adaptation (50).”
Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “This concept is supported by a study showing that cold-induced UCP1+ cells acquire a white-like unilocular morphology after the animals are warmed and that these same cells reactivate UCP1 in response to another bout of cold (Rosenwald et al., 2013).”
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, positive): “These white adipocytes can reconvert into beige adipocytes after additional cold stimulation (43).”
Adipose tissue plasticity in health and disease (2022, background): “However, ‘‘previously beige’’ cells rapidly reactivate the thermogenic program upon a second exposure to cold (Rosenwald et al., 2013).”