Neurobiology of Resilience
By S. Russo, J. Murrough, Ming-Hu Han, Dennis S. Charney, E. Nestler. Nature Neuroscience, 2012
1,137 citations recorded by the source corpus.
Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correlative neuroendocrine markers that are associated with a resilient phenotype. In this review, we highlight a growing literature in rodents that is starting to complement the human work by identifying the active behavioral, neural, molecular and hormonal basis of resilience. The therapeutic implications of these findings are important and can pave the way for an innovative approach to drug development for a range of stress-related syndromes.
Subfields: Behavioral Neuroscience, Biological Psychiatry, Physiology
View Paper: https://www.semanticscholar.org/paper/3176fc444f969c4173b75b515ad52f1adbfb9d7d
How researchers see this paper
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In Behavioral Neuroscience
- A. Feder
- Isaac R. Galatzer-Levy
- David Sander
- Henrik Walter
- Guillén Fernández
- Tor D. Wager
- Erno J. Hermans
- G. Bonanno
In Biological Psychiatry
In Physiology
Citations in the corpus
- Resilience in farm animals: biology, management, breeding and implications for animal welfare (2016, methodology): “…recent years, a broader concept of resilience has emerged in animal and human sciences that encompasses not only the response of the individual to disease challenges but also the individual’s response to environmental and social stressors (Russo et al. 2012;Wu et al. 2013;Hermesch andDominik 2014).”
- EMPLOYEE RESILIENCE: DIRECTIONS FOR RESILIENCE DEVELOPMENT (2017, background): “, moderate stress exposure) and situational reframing (e.g., perspective on resources and their availability; Russo et al., 2012).”
- Understanding resilience (2013, background): “This complex set of feedback interactions constitutes the HPA axis, which is a key neuroendocrine player modulating behavioral responses to stress (Russo et al., 2012).”
- The resilience framework as a strategy to combat stress-related disorders (2017, positive): “To summarize, most resilience theorists currently agree that resilience is not simply inertia or insensitivity to stressors, or merely a passive response to adversity, but the result of active, dynamic adaptation 28 .”