Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins.

By A. MacGregor, Harold Snieder, A. Rigby, M. Koskenvuo, Jaakko Kaprio, K. Aho, A. Silman. Arthritis & Rheumatism, 2000

1,243 citations recorded by the source corpus.

Subfields: Genetics, Nephrology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/316dbbd1c0c15e3f22b82f3d2923dfa52e3c2f97

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Robert M. Plenge
2. Kristin G. Ardlie
3. Eli A. Stahl
4. Matthew Stephens
5. Jeffrey T. Leek
6. Edward S. Buckler

In Rheumatology

1. P. Tak

Citations in the corpus

• Epidemiology and genetics of rheumatoid arthritis (2002, background): “Data from twin studies in the HLA association and sharing studies have been used to estimate that only 50% of the genetic contribution to RA can be explained by HLA [24].”
• Management of Rheumatoid Arthritis: An Overview (2021, background): “The genetic risk for RA that has been estimated by scientific studies is about 50% [40,41].”
• Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. (2005, background): “Despite the phenotypic heterogeneity encompassed by this disease definition, the genetic contribution is estimated to be 50–60% ( 1 ), with the HLA”
• A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. (2004, neutral): “A strong genetic component is indicated (Seldin et al. 1999; MacGregor et al. 2000), and genome scans have identified multiple regions linked to disease (Cornelis et al. 1998; Shiozawa et al. 1998; Jawaheer et al. 2001, 2003; MacKay et al. Received April 30, 2004; accepted for publication May 25,…”
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci (2010, background): “It is clear that additional risk alleles remain to be identified, as current genetic discoveries explain only 16% of disease variance (including an estimated 12% for the MHC regio”
• Nature or Nurture: What Determines Investor Behavior? (2010, neutral): “, Nicolaou et al. (2008) and Zhang et al.”