Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.

By V. Papadopoulos, M. Baraldi, Tomás R. Guilarte, T. Knudsen, J. Lacapere, P. Lindemann, M. Norenberg, David J. Nutt, Abraham Weizman, Ming-Rong Zhang and 1 more. TIPS - Trends in Pharmacological Sciences, 2006

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The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed transmembrane protein that is located mainly in the outer mitochondrial membrane. The PBR binds to high-affinity drug ligands and cholesterol. Many functions are associated directly or indirectly with the PBR, including the regulation of cholesterol transport and the synthesis of steroid hormones, porphyrin transport and heme synthesis, apoptosis, cell proliferation, anion transport, regulation of mitochondrial functions and immunomodulation. Based on these functions, there are many potential clinical applications of PBR modulation, such as in oncologic, endocrine, neuropsychiatric and neurodegenerative diseases. Although "PBR" is a widely used and accepted name in the scientific community, recent data regarding the structure and molecular function of this protein increasingly support renaming it to represent more accurately its subcellular role (or roles) and putative tissue-specific function (or functions). Translocator protein (18kDa) is proposed as a new name, regardless of the subcellular localization of the protein.

Subfields: Cellular and Molecular Neuroscience, Clinical Biochemistry, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/31650618179f4677c8b0ed45c77b252f79342046

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Citations in the corpus

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. (2011, background): “This is consistent with the physiological role of PBR as a multi-functional mitochondrial outer membrane protein that can participate in the antioxidant stress response system (Papadopoulos et al., 2006).”
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders (2010, positive): “jpg"/> The translocator protein (18 kDa) (TSPO) is a five transmembrane domain protein that is localized primarily in the outer mitochondrial membran”