RNA interference (RNAi) in the Nucleus: roles for small RNA in transcription, epigenetics and beyond

By Stephane E. Castel, R. Martienssen. Nature reviews genetics, 2013

939 citations recorded by the source corpus.

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm. Epigenetic modifications directed by small RNAs have been shown to cause transcriptional repression in plants, fungi and animals. Additionally, increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery. Nuclear small RNAs include small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) and are implicated in nuclear processes such as transposon regulation, heterochromatin formation, developmental gene regulation and genome stability.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/3163e7d14c51f6aea916858b45de76edc55539c6

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Citations in the corpus

• Transgenerational Epigenetic Inheritance: myths and mechanisms (2014, neutral): “RNAi promotes the release of RNA polymerase II and prevents DNA damage and defects in heterochromatin repair (Castel and Martienssen, 2013; Keller and Bühler, 2013).”
• Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “For detailed reviews on miRNA biology, see Ha and Narry Kim (98) or Castel and Martienssen (40).”
• MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions (2016, background): “We know that siRNAs can regulate gene transcription [80], thus derogating from the most consolidated activity of RNA interference.”