Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

By S. Rost, A. Fregin, V. Ivaškevičius, E. Conzelmann, K. Hörtnagel, H. Pelz, K. Lappegård, E. Seifried, I. Scharrer, E. Tuddenham and 3 more. Nature, 2004

1,181 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Pharmacology

View Paper: https://www.semanticscholar.org/paper/3148686f064ed497389e04e8858bc034c616f18b

How researchers see this paper

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In Molecular Biology

1. Feras Hatahet
2. Shufeng Zhou
3. Shan Zhao
4. P. Hedrick
5. Ravi Iyengar

In Nutrition and Dietetics

1. P. Hedrick

In Pharmacology

1. Shufeng Zhou
2. Jun-Ping Liu
3. Shan Zhao
4. B. Chowbay
5. Ravi Iyengar

Citations in the corpus

• Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action (2012, background): “Sometimes SNPs fall within the coding regions of genes, leading to changes in protein primary sequences and activity (21).”
• Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation (2009, background): “The vitamin K 2,3-epoxide formed from this reaction is then reduced back to vitamin K hydroquinone by the action of vitamin K 2,3-epoxide reductase (VKOR) (227, 255).”
• Genetic Polymorphism in Heterogeneous Environments: The Age of Genomics (2006, methodology): “Sabeti et al. (2005) used human genomic diversity data to suggest that aspects of the CCR5- 32 data, including linkage disequilibrium, are not significantly different from other variants at the locus or throughout the human genome.”
• Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “Warfarin and other coumarin anticoagulants exert an anticoagulant effect by inhibiting the enzymatic activity of vitamin K 1 2,3-epoxide reduct- ase complex 1 (VCORC1) (Goodstadt and Ponting, 2004; Rost et al., 2004).”