Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

By I. García-Higuera, T. Taniguchi, Shridar Ganesan, M. Meyn, Cynthia Timmers, J. Hejna, M. Grompe, A. D’Andrea. Molecules and Cells, 2001

1,288 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/31337df3e991fa6fe633fbe6fe990ef99ea84094

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Abraham
2. S. West
3. Aaron Ciechanover
4. Ji Luo
5. M. Glickman
6. M. Jasin
7. Stephen J. Elledge
8. G. Gill

In Molecular Biology

1. S. West
2. R. Abraham
3. Stephen J. Elledge
4. M. Jasin
5. Aaron Ciechanover
6. A. D’Andrea
7. Kay Hofmann
8. Ji Luo

Citations in the corpus

• SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? (2004, background): “Studies of the Fanconi Anemia protein FANCD2 have shown that monoubiquitin also regulates subnuclear localization (Garcia-Higuera et al. 2001).”
• A 20-year perspective on the International Fanconi Anemia Registry (IFAR). (2003, background): “Yes 601 (80) No 153 ( 20 ) HSCT”
• Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. (2007, methodology): “To test if monoubiquitination of FANCD2 was required for this interaction, PD20 cells complemented with wild-type (wt) or the K561R mutant of FANCD2 that cannot be monoubiquitinated (Garcia-Higuera et al., 2001) were used in immunoprecipitation experiments.”
• A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2 (2012, background): “To directly assess if fork protection requires FA pathway activation by monoubiquitination of FANCD2, we analyzed nascent replication tracts in PD20 cells expressing mutant FANCD2K561R incapable of being ubiquitinated (Ub) (Garcia-Higuera et al., 2001).”
• Spectrum of sequence variations in the FANCA gene: An International Fanconi Anemia Registry (IFAR) study (2003, background): “Proteins A, C, E, F, G, and L assemble in a nuclear complex that activates the monoubiquitination of the downstream D2 protein, thereby targeting D2 to BRCA1-containing nuclear foci [Garcia-Higuera et al., 2001, Meetei et al., 2003].”
• The emerging genetic and molecular basis of Fanconi anaemia (2001, background): “What are the crucial downstream effector molecules in the pathway? Cell lines from complementation group D seem to have an intact nuclear core comple”
• The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. (2002, background): “Affected patients display high sensitivity to mitogens and irradiation, which result in high frequency of malignancies (118).”