Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.
By R. Linker, De-hyung Lee, Sarah Ryan, A. van Dam, R. Conrad, Pradeep Bista, Weike Zeng, Xiaoping Hronowsky, A. Buko, Sowmya Chollate and 8 more. Brain : a journal of neurology, 2011
1,091 citations recorded by the source corpus.
Subfields: Molecular Biology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/310e6474bfac3e14a0fe15a46b6ab32da2e5a5a7
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Citations in the corpus
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, neutral): “Administration of the Nrf2 inducer dimethyl fumarate in MS models showed reduced levels of oxidative stress and preservation of nerve fiber myelination, which is lost in Nrf2−/− mice [488, 489].”
- An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation (2020, background): “In vivo studies in rodents had reported that DMF metabolite, monomethyl fumarate, activates Nrf2 by adduct formation at C151 in Keap1 in neuroinflammation [238].”
- Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism (2016, background): “demonstrated that beneficial effects of DMF in murine experimental autoimmune encephalomyelitis (EAE), a mouse model of MS are mainly due to activation of Nrf2 [163].”
- NRF2 and cancer: the good, the bad and the importance of context (2012, positive): “Potent protection against aflatoxin‐induced tumorigenesis through induction of Nrf2‐regulated pathways by the triterpenoid1‐ [2‐cyano‐3‐,12‐dioxooleana‐1,9(11)‐dien‐28‐oyl]”