Notch signals control the fate of immature progenitor cells in the intestine

By Silvia Fre, M. Huyghe, P. Mourikis, S. Robine, D. Louvard, S. Artavanis-Tsakonas. Nature, 2005

974 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/30f4f9ae3b4e730fa73d44dbc80226853f7303b4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

When NRF2 Talks, Who's Listening? (2010, positive): “Activation of the pathway has been shown to be a potent inhibitor of differentiation in different developmental contexts and has been associated with the ampliﬁcation of certain somatic stem cells (27, 35, 64, 80, 134, 142).”
Epithelial stem cells: turning over new leaves. (2007, neutral): “, 2005) whereas the knockout of Math1 or gain-of-function mutations in Notch leads to the opposite phenotype (Fre et al., 2005; Stanger et al., 2005; Yang et al., 2001).”
Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. (2006, background): “Our data argue for a direct influence of the microbiota on cell fate specification in the gut, a developmental pathway known to be regulated by Notch signaling (Crosnier et al., 2005; Fre et al., 2005; Stanger et al., 2005), or alternatively, a differential effect of the microbiota on the lifespan o”
The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “The bHLH activator gene Math1, a mammalian homolog of the Drosophila proneural gene atonal, promotes the development of goblet, enteroendocrine and Paneth cells, whereas the activation of Notch-Hes1 signaling represses Math1, and thereby inhibits the generation of Math1-dependent cells (Jensen et al”
Wnt signaling in cancer. (2012, result): “The impact of Notch in the intestine was consistent with previous work showing that its activation or inhibition increased or decreased the population of proliferating/progenitor cells, respectively, at the expense of the differentiated population (Fre et al. 2005; van Es et al. 2005).”
The intestinal crypt, a prototype stem cell compartment. (2013, background): “NICD translocates to the nucleus, where it binds the transcription factor CSL, thus activating transcription of target genes.”
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche (2009, background): “Notch signals are similarly essential, with stimulation amplifying the progenitor pool and inhibition resulting in large-scale conversion to post-mitotic goblet cell”