The origins of protein phosphorylation

By P. Cohen. Nature Cell Biology, 2002

1,129 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/30f3b1ea04edfafb5ec0adea26893f622e18c0d2

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Citations in the corpus

One‐thousand‐and‐one substrates of protein kinase CK2? (2003, background): “As mentioned in a recent historical review on the origins of protein phosphorylation (1), the first protein kinase activity was discovered in 1954 by Burnett and Kennedy (2) (for an amusing recollection, see E.”
Protein kinases — the major drug targets of the twenty-first century? (2002, background): “jpg" NDATA ITEM> ]> Protein phosphorylation was originally identified as a regulatory mechanism for the control of glycogen metabolism, and it took many more years before its general significance came to be appreciate”
Developing irreversible inhibitors of the protein kinase cysteinome (2013, neutral): “Protein phosphorylation can induce a myriad of consequences including modulation of enzyme activity, conformation, stability, localization, and association with other proteins or small molecules (Cohen, 2002).”
The growing landscape of lysine acetylation links metabolism and cell signalling (2014, background): “Interestingly, HDAC1, HDAC2 and HDAC3 also bind to inositol-1,4,5,6-tetraphosphate (Ins(1,4,5,6)P4), which facilitates the binding of these HDACs to co-repressor complexes and increases the catalytic activity of the deacetylases75.”
Mapping protein post-translational modifications with mass spectrometry (2007, background): “It is estimated that one-third of eukaryotic proteins are phosphorylated, a result of carefully regulated protein kinase and phosphatase activitie”
The Functional Organization and Control of Plant Respiration (2006, background): “Enzyme control by reversible covalent modification plays a dominant role in fine metabolic control and is the major mechanism whereby extracellular stimuli such as hormones or light coordinate the control of intermediary metabolism ( Cohen, 2002 ; Huber and Hardin, 2004 ; Plaxton, 2004b ; Moorhead”
Phosphorylation: Implications in Cancer (2017, background): “Importance of this process became apparent with further researches which showed its involvement in almost every cellular process [7].”
Phospho.ELM: A database of experimentally verified phosphorylation sites in eukaryotic proteins (2004, neutral): “translational modification in intracellular proteins [1,2] and is an important mechanism for modulating (regulating) many cellular processes such as proliferation, differentiation and apoptosis.”