A simple method for displaying the hydropathic character of a protein.

By J. Kyte, Russell F. Doolittle. 1982

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Citations in the corpus

Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks (2011, methodology): “For example, while our classification is roughly based on the scale derived by Wimley and White [21], the classification scheme by Kyte and Dolittle [22] considers Y and W as hydrophilic amino acids.”
MOLE 2.0: advanced approach for analysis of biomacromolecular channels (2013, background): “0, the charge according to the amino acid sidechain type (Arg, Lys +1e; Glu, Asp −1e), hydropathy [43], hydrophobicity [44], mutability [45] and polarity [46] are computed.”
Design of a specific peptide against phenolic glycolipid-1 from Mycobacterium leprae and its implications in leprosy bacilli entry (2022, background): “Since the expected PGL-1 molecule displayed a low solubility in aqueous solutions, we selected the peptide based on the best hydrophobic scores, and the key criteria was that peptides with positive values, compared to those with negative values, are more hydrophobic and thereby less soluble.(15) Ano”
The Human Gene Mutation Database: 2008 update (2009, unknown): “This includes curatorial comments pertaining to particular mutations (for example if the mutation data required correction in relation to the data presented in the original publication), and comparative biochemical information (including change in residue polarity, pH, weight, hydrophobicity [30,31]”
BindN: a web-based tool for efficient prediction of DNA and RNA binding sites in amino acid sequences (2006, methodology): “We used the hydrophobicity scale developed by Kyte and Doolittle (15) to assign the feature values in this study.”
Potential role of phospholipases in virulence and fungal pathogenesis. (2000, background): “Hydropathy analysis of the predicted protein (98) revealed the presence of a cluster of hydrophobic amino acids at the N terminus.”
Pocketome via Comprehensive Identification and Classification of Ligand Binding Envelopes* (2005, methodology): “rameter ( 33 ) and electrostatic charge) were used to characterize the envelope.”
Flexible sequence similarity searching with the FASTA3 program package. (2000, methodology): “tgrease Calculates the hydropathy plot of a protein sequence using the KyteDoolittle method (26).”
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. (2002, unknown): “amino acid sequence and the analysis of hydrophobicity of the translated protein (30) predicts that the protein has two hydrophobic regions, one located in the amino terminus from amino acids 1–16, which likely represents a signal peptide, and another in the carboxy terminus from amino acids 306–326”