IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

By M. Teng, E. Bowman, J. McElwee, M. Smyth, J. Casanova, A. Cooper, D. Cua. 2015

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Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “While IL-12 induces differentiation of IFN-γ producing Th1 cells, IL-23 reinforces and shapes the Th17 cell response (Teng et al., 2015).”
Mechanisms of Disease: Inflammatory Bowel Diseases. (2019, background): “Studies have shown that mice deficient in IL-12 p40 subunit and deficient in IL-23 are resistant to experimentally induced colitis suggesting that these cytokines are in the center of the CD inflammatory pathway (99, 100).”
NF-κB signaling in inflammation (2017, neutral): “2,91,92 Deregulated activation of NF-κ B also contributes to aberrant survival of self-reactive B cells and production of auto-antibodies that contribute to the pathogenesis of RA.”
Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1 (2017, background): “Given the paucity of structural information for any IL-12 family complex and the growing importance of specific therapeutic targeting of human IL-23 (Teng et al., 2015), we pursued structural studies of human IL-23 and its complexes with the ectodomains of its specific receptor IL-23R and the…”