Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

By Min Yu, A. Bardia, Ben S. Wittner, Shannon L. Stott, Malgorzata E. Smas, D. Ting, S. Isakoff, Jordan C. Ciciliano, Marissa N. Wells, Ajay M Shah and 10 more. Science, 2013

2,310 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/303d7f19553631897a27943739af9617b581d542

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. Raghu Kalluri
5. Yibin Kang
6. K. Yeung
7. X. Ye
8. Xiawei Wei

In Oncology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. J. Tsai
5. Raghu Kalluri
6. X. Ye
7. Yibin Kang
8. K. Yeung

In Pulmonary and Respiratory Medicine

1. R. Weinberg
2. M. Nieto
3. X. Ye
4. Raghu Kalluri
5. E. Hay

Citations in the corpus

• Circulating Tumor Cell Clusters are Oligoclonal Precursors of Breast Cancer Metastasis (2014, methodology): “In human breast cancer CTCs, we recently documented marked enrichment for mesenchymal transcripts in CTCs, using quantitative RNA-in situ hybridization (Yu et al., 2013).”
• PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation to promote metastasis (2014, neutral): “Focal hypoxia may induce an EMT program(16, 26), and our results indicate that while cancer cells acquire a mesenchymal phenotype (EMT) independently of PGC-1α-induced pathways, both pathways coexist and are associated with cancer cell migration, invasion and metastasis(27).”
• Epithelial-mesenchymal plasticity in cancer progression and metastasis (2019, background): “As discussed earlier, tumor cells often undergo an incomplete EMT during metastasis and recent studies have confirmed the existence of these partial EMT states during tumor progression in vivo (Pastushenko et al., 2018; Yu et al., 2013).”