Identification of the familial cylindromatosis tumour-suppressor gene
By G. Bignell, W. Warren, S. Seal, Meiko Takahashi, E. Rapley, R. Barfoot, H. Green, Carolanne Brown, Patrick J. Biggs, Sunil R. Lakhani and 31 more. Nature Genetics, 2000
725 citations recorded by the source corpus.
Subfields: Cancer Research, Dermatology, Epidemiology
View Paper: https://www.semanticscholar.org/paper/2fd755c26f1b4f33ed8ddb9cdc42f7a3d79c1168
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In Cancer Research
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- Weimin He
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In Epidemiology
Citations in the corpus
- 30 years of NF-κB: a blossoming of relevance to human pathobiology (2017, neutral): “Later, a large cohort of cylidromatosis patients helped to identify CYLD as a tumor suppressor gene and NF-κB regulator (Bignell et al., 2000).”
- Deubiquitylating enzymes and drug discovery: emerging opportunities (2017, background): “In this Review, we discuss these issues and highlight recent advances in our understanding of DUB enzymology and biology as well as technological improvements that have contributed to the current interest in DUBs as therapeutic targets in diseases ranging from oncology to neurodegeneration. in cance”
- Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB (2003, methodology): “This was immunoprecipated with either non-immune serum (n.i.) or Flag antibody from both untreated cells (basal) or cells treated for 20 min. with TNF-a(20 0 ) and lysates were incubated with GST-IkBa (1-72) in the presence of 32P-gATP (upper panel).”
- Mechanism and function of deubiquitinating enzymes. (2004, background): “The first human disorder linked to a heritable genetic defect in a DUB was cylindromatosis (turban tumor syndrome) [96].”