Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

By J. Ratajczak, K. Miękus, M. Kucia, Jin Zhang, R. Reca, P. Dvořák, M. Ratajczak. Leukemia, 2006

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In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior (2015, background): “In vitro assays showed that EV cargo, such as mRNA, is functional in cells that take up EVs (Valadi et al., 2007), leading to behavioral changes of recipient cells (Ratajczak et al., 2006; Salomon et al., 2013).”
Exosomes: secreted vesicles and intercellular communications (2011, background): “Of note, mRNA has also been described in microvesicles (or mixed exosome/microvesicle preparations) released by tumors or embryonic stem cells [21-23], and some ongoing studies are now comparing sequences of RNA targeted to either exosomes or larger vesicles, and determining whether there is a disti”