Neocortex Patterning by the Secreted Signaling Molecule FGF8

By T. Fukuchi-Shimogori, E. Grove. Science, 2001

697 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2f5d263b5c14d5c9153006c6fd3484c47418892f

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Cortex and Memory: Emergence of a New Paradigm (2009, background): “…cortical volume (Northcutt & Kaas, 1995; Rockel, Hiorns, & Powell, 1980) resulting from evolutionary duplication of areas by genetic mutation (Fukuchi-Shimogori & Grove, 2001; Rakic, 2001); (2) an ontogenetic gradient of increasing myelination and maturation (Barkovich, 1995; Conel, 1963);…”
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window (2009, neutral): “For example, in utero electroporation in mouse embryos has been used to label large groups of neurons in neocorte”
Building drug delivery into tissue engineering design (2002, background): “cgi?l=2253">FGF8 ) influence the cytoarchitectonic map of the corte”
How the Timing and Quality of Early Experiences Influence the Development of Brain Architecture (2010, positive): “Fgf8 alone is sufficient to specify the cortical regions that will eventually receive connections that are typical of frontal and somatosensory cortices (Fukuchi-Shimgori & Grove, 2001, 2003).”
The functional organization of the barrel cortex. (2007, background): “For example, gradients of secreted FGF8 during embryonic development can determine both the position and dimensions of the barrel field in the neocortex (Fukuchi-Shimogori and Grove, 2001; Figure 5A).”
Area patterning of the mammalian cortex. (2007, background): “Anterior overexpression of Fgf8 by in utero electroporation is sufficient to shift cortical areas posteriorly; in contrast, a similar electroporation of a soluble form of Fgfr3 that acts as an inhibitor of Fgf8 shifts areas anteriorly (Fukuchi-Shimogori and Grove, 2001) (Figure 2C).”
Genetic dissection of neural circuits. (2008, positive): “Systematic protein-protein and transcription factor-DNA interactions contribute to deciphering the gene networks.”