Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.

By R. Feng, C. Rampon, Y. Tang, D. Shrom, J. Jin, M. Kyin, B. Sopher, M. W. Miller, C. Ware, G. Martin and 4 more. 2001

487 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “…of human presenillin (PS) variants linked to early-onset familial Alzheimer's disease in microglia impairs proliferation and neuronal fate commitment (Choi et al., 2008), whereas deletion of PS1 in forebrain excitatory neurons affects enrichment-induced hippocampal neurogenesis (Feng et al., 2001).”
The organization of recent and remote memories (2005, background): “Another interesting possibility is that adult neurogenesis contributes to the clearance of hippocampal trace”
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, background): “…in Neurosciences and Mental Health, Hospital for Sick Children Research Institute, Toronto, Canada M5G 1X8 6Present address: Institute for Comprehensive Medical Science, Fujita Health University, Aichi 470-1192, Japan *Correspondence: inokuchi@med.u-toyama.ac.jp DOI 10.1016/j.cell.2009.10.020”
Long‐chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes (2008, background): “Mutations of PS1 are responsible for the early onset of AD due to increased production of b-amyloid plaques (Feng et al., 2001; McGuire and Davis, 2001; Popescu and Ankarcrona, 2004).”
Excitation-neurogenesis coupling in adult neural stem/progenitor cells. (2004, background): “…within the hippocampus are inconsistent; for example, adult neurogenesis has been variously im- dent neurogenesis may affect the future learning of new memories or the degradation and clearance of pre-plicated in either the storage or clearance of memories (Feng et al., 2001; Shors et al., 2001).”
New circuits for old memories: the role of the neocortex in consolidation. (2004, unknown): “The highly intercon-ance of hippocampal memories (Feng et al., 2001).”
The Biology of Forgetting – A Perspective (2017, background): “Neurogenesis remodels hippocampal circuits and has been suggested as a mechanism for clearing memory traces (Feng et al., 2001; Deisseroth et al., 2004).”