Synaptogenesis in human visual cortex--evidence for synapse elimination during normal development.

By P. Huttenlocher, C. de Courten, L. J. Garey, H. van der Loos. 1982

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Citations in the corpus

Critical Learning Periods in Deep Neural Networks (2017, background): “Notice that a similar phenomenon is observed in the development of neuronal networks (Figure 4, Center), where the density of synaptic connections rapidly peaks during early development and slowly decreases afterwards as a results of synaptic pruning (44, 45).”
Structural Synaptic Plasticity Has High Memory Capacity and Can Explain Graded Amnesia, Catastrophic Forgetting, and the Spacing Effect (2014, background): “Such homeostatic regulation of generation and elimination of synapses is even more evident during adulthood where the anatomical connectivity appears almost stable over several decades [14,51,77].”
Normal Development of Brain Circuits (2010, methodology): “…age 3 and 4 months, synaptic density reaches its peak at 140–150% of adult levels between the ages of 4 and 12 months, after which the mean number of synapses per neuron decline (Bourgeois, 1997; Bourgeois and Rakic, 1993; Huttenlocher, 1990; Huttenlocher et al, 1982a, b; Michel and Garey, 1984).”
Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species (2013, background): “The timing of this synapse proliferation is region-dependent; for example, synaptic density peaks in the primary visual cortex as earlyas8–12 months of age, compared to 2–4 years of age in the prefrontal cortex (Huttenlocher et al., 1982; Lenroot and Giedd, 2006).”
Regional differences in synaptogenesis in human cerebral cortex (1997, background): “Data are most complete for calcarine cortex (area 17 of Brodmann), including synaptic density values in all cortical layers and estimates of total number of synapses at various ages (Huttenlocher et al., 1982; Huttenlocher and de Courten, 1987).”
The teen brain: insights from neuroimaging. (2008, background): “[73] Huttenlocher PR, de Courten C, Garey LJ, Van Der Loos H.”
Synaptic Pruning in Development: A Computational Account (1998, background): “widespread brain regions including cortical areas: visual (Bourgeois & Rakic, 1993; Huttenlocher et al., 1982), motor and associative (Huttenlocher, 1979), the cerebellum(Takacs & Hamori, 1994), projection fibers between hemispheres (Innocenti, 1995), and the dentate gyrus (Eckenhoff & Rakic, 1991).”
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, unknown): “Interestingly, changes of synapse density in the developing human cortex follow an identical time course (Huttenlocher, 1979; Huttenlocher et al., 1982).”