Design Considerations for Tumor-Targeted Nanoparticles

By Hak Soo Choi, Wenhao Liu, Fangbing Liu, Khaled A. Nasr, P. Misra, Moungi G. Bawendi, John V. Frangioni. Nature Nanotechnology, 2009

690 citations recorded by the source corpus.

DIAGNOSTIC AGENTS Nanoparticles functionalized with ligands that target tumors can be cleared from the body through the kidneys if they have a hydrodynamic diameter of less than 5.5 nm.

Subfields: Electronic, Optical and Magnetic Materials, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/2ee2cb75df9cef715f3fe9c660318141214824a0

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In Electronic, Optical and Magnetic Materials

1. Shuming Nie

In Materials Chemistry

1. Shuming Nie
2. John V. Frangioni
3. Hak Soo Choi

Citations in the corpus

• The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, neutral): “5 nm [102,103], and carbon nanotubes [104,105].”
• Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation (2010, background): “Only neutral or certain hydrophilic surfaces (eg, zwitterionic) and neutral surfaces can prevent plasma protein adsorption.(18,20,40) In summary, intravenous injection ensures that an NP can potentially have access to the entire body, but normal vascular physiology will restrict NP biodistribution a”