RAS Proteins and Their Regulators in Human Disease.

By D. Simanshu, D. Nissley, F. McCormick. Cell, 2017

1,672 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2ec43bc027ac291ca67f760808253053723f0b2f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Fiona E. Hood
2. J. Hartley
3. Wei-Wei Pan
4. Z. Shen
5. Sheng-Bing Liu
6. Yan-Jun Guo
7. Lingji Hu
8. Ying Xu

Citations in the corpus

• The frequency of Ras mutations in cancer (2020, background): “The collated pancreatic data reveals a consistent anomaly: according to literature sources 90%–98% of pancreatic cancers are KRAS mutated (1, 3, 42); while most datasets contain lower values of 70%–75% (Supplementary Table S1).”
• ERK/MAPK signalling pathway and tumorigenesis (2020, background): “SOS and Ras-GDP promote the replacement of GDP with GTP in Ras, thereby activating Ras to initiate the Ras pathway (44) (Fig.”
• The Tumor Suppressor Protein p53 and the Ferroptosis Network (2018, neutral): “These oncogenes therefore are highly attractive targets for anticancer drug discovery, colliding with the fact that thus far no direct RAS inhibitors have been introduced into clinical practice [19].”