Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.

By N. Goardon, E. Marchi, A. Atzberger, L. Quek, A. Schuh, S. Soneji, P. Woll, A. Mead, K. Alford, R. Rout and 24 more. Cancer Cell, 2011

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chromVAR: Inferring transcription factor-associated accessibility from single-cell epigenomic data (2017, result): “In addition, we also observe that patient 1 (AML blast 1) maintains a more stem-like state when compared to patient 2 (AML blast 2) as anticipated from alternate analyses of these cells 16 .”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “(E) If multiple populations have leukemogenic capacity but do not interconvert, then only the most immature cells can recapitulate the full heterogeneity of the parent leukemia, but multiple levels of the hierarchymay be able to drive disease progression (Goardon et al., 2011).”
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. (2011, neutral): “In human acute leukemia, this crucial property can be acquired by committed progenitors with limited self-renewal capacities through a genetic event or maintained through the targeting of hematopoietic stem cells (HSCs) (Cozzio et al., 2003; Goardon et al., 2011; Huntly et al., 2004).”
Hematopoiesis: a human perspective. (2012, result): “Similar findings were reported using Thy1CD45RA cells from adult BM (Goardon et al., 2011).”