The metabolic syndrome, inflammation, and risk of cognitive decline.

By Kristine Yaffe, A. Kanaya, K. Lindquist, Eleanor M. Simonsick, T. Harris, R. Shorr, Fran Tylavsky, Anne B. Newman. Journal of the American Medical Association (JAMA), 2004

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease (2009, neutral): “Evidence shows that the clustering of metabolic risk markers in adulthood is associated with elevated risk of developing cardiovascular disease, diabetes, and dementia in later life.(18,20) Importantly, depression, inflammation, and the clustering of metabolic risk markers frequently cooccur in the ”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “, 2008) and aged individuals with the metabolic syndrome (Yaffe et al., 2004).”
Microglia and neurodegeneration: The role of systemic inflammation (2013, background): “betes, atherosclerosis, arthritis all have a systemic inflammatory component (Yaffe et al., 2004).”
The metabolic syndrome. (2003, neutral): “Elderly patients with the metabolic syndrome were more likely to have cognitive impairment than those without [45].”
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, positive): “However, over the past 10 years or so, research has identified a key role for inflammation in the pathophysiology of each of the aforementioned conditions (Chen & Miller, 2007; Choy & Panayi, 2001; Glass, Saijo, Winner, Marchetto, & Gage, 2010; Mantovani, Allavena, Sica, & Balkwill, 2008; Marx, 2004”