The metabolic syndrome.
By R. Eckel, S. Grundy, P. Zimmet. The Lancet, 2003
2,308 citations recorded by the source corpus.
The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.
Subfields: Endocrinology, Diabetes and Metabolism, Physiology
View Paper: https://www.semanticscholar.org/paper/ebac4c649876f0b8758590a3ddb4af185ad74a57
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Citations in the corpus
- Association between insulin resistance and the development of cardiovascular disease (2018, background): “Cellular mechanisms of insulin resistance Insulin works on multiple processes, essentially providing an integrated set of signals that allows the correct balance between nutrient supply and demand [33].”