Towards an understanding of the adjuvant action of aluminium

By P. Marrack, A. McKee, M. Munks. Nature reviews. Immunology, 2009

890 citations recorded by the source corpus.

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

Subfields: Genetics, Nutrition and Dietetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/2de31592dcd37fa26a79481c337f57b7c0b7c98c

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Citations in the corpus

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity1 (2009, background): “However, whether Nlrp3 and IL-1 /IL-18 play a role in the adjuvant activity of aluminum salt alone is a matter of debate (21).”
Mechanisms of Action of Adjuvants (2013, background): “The conflicting results with regard to the role of inflammasomes in adjuvant activity of alum have been attributed to the differences in the nature of alum used in different studies, immunization protocols, and the mouse strains used (De Gregorio et al., 2008; Marrack et al., 2009).”
'ASIA' - autoimmune/inflammatory syndrome induced by adjuvants. (2011, background): “In doing so, aluminium stimulates the production and secretion of cytokines such as IL-1b; IL-18 and IL-33 [14].”