Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement

By J. Dalley, T. Fryer, L. Brichard, E. Robinson, D. Theobald, Kristjan Lääne, Y. Pena, Emily R. Murphy, Yasmene Shah, K. Probst and 7 more. Science, 2007

1,214 citations recorded by the source corpus.

Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine (DA) function before drug exposure. Using positron emission tomography, we demonstrated that D2/3 receptor availability is significantly reduced in the nucleus accumbens of impulsive rats that were never exposed to cocaine and that such effects are independent of DA release. These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2dc2fe2a7d35db6d5302562d05b220e279b7a562

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Citations in the corpus

Insights into the neural basis of response inhibition from cognitive and clinical neuroscience. (2009, neutral): “An animal model of impulsivity, characterized as an inability to delay a reward-related response, has been linked to reduced D2 receptor levels in the ventral striatum (Dalley et al., 2007).”
Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors (2008, background): “Similarly preclinical studies have shown that animals with low D2 receptor levels are more impulsive than their littermates with high D2 receptor levels (Dalley et al., 2007).”
Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “, 2005) or premature responses on an attentional task (Dalley et al., 2007).”
What is reinforcement sensitivity? Neuroscience paradigms for approach‐avoidance process theories of personality (2008, background): “Dalley et al. (2007) outbred Lister hooded rats on the basis of anticipatory 3Non-biologically oriented specialists in emotion and motivation will almost certainly perceive limitations of this approach to their domain.”
A delay-discounting primer. (2010, background): “With recent findings that the latter two appear to precede and predict drug taking in rodents (Dalley et al., 2007; Diergaarde et al., 2008; Carroll, Anker, Mach, Newman, & Perry, this volume), we anticipate these activities will be the focus of much study of impulsivity and addictive behaviors for…”
Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “However, we could ﬁnd no evidence of increased activity in photocell cages in our high-impulsive 5CSRTT animals (Dalley et al., 2007), suggesting that reactivity to novelty is not core to the impulsivity construct.”