A dimorphic pheromone circuit in Drosophila from sensory input to descending output

By V. Ruta, Sandeep R. Datta, M. Vasconcelos, J. Freeland, L. Looger, R. Axel. 2010

342 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Insect Science

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “All functional imaging experiments were performed on an Ultima two-photon laser-scanning microscope (Bruker Nanosystems) as previously described (Ruta et al., 2010).”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, methodology): “We employed an independent approach, photoactivatable GFP (PA-GFP) tracing (Patterson and Lippincott-Schwartz, 2002; Datta et al., 2008; Ruta et al., 2010), to verify the results of the splitGAL4 experiments and determine whether the neuron types identified in our screen represent the full…”
Genetic manipulation of genes and cells in the nervous system of the fruit fly (2011, methodology): “Photoactivatable GFP has been used to follow particular neural input pathways (Datta et al., 2008; Ruta et al., 2010).”
Feed-Forward versus Feedback Inhibition in a Basic Olfactory Circuit (2015, background): “In the fly there is evidence that the LH processes odors that carry meaning innately [41, 48].”
Analysis of functional neuronal connectivity in the Drosophila brain. (2012, methodology): “Although other methods to detect physiologic connectivity have recently been used in the fly brain (e.g., Hu et al. 2010; Ruta et al. 2010), we feel that the approach outlined here has the virtue of a relative technical simplicity, requiring only standard confocal or epifluorescent microscopy and a…”
Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. (2019, background): “DA1 PNs form stereotyped synapses in the lateral horn onto the neuron aSP-f in 99 males, and aSP-g in females [24-26].”
Imaging a Population Code for Odor Identity in the Drosophila Mushroom Body (2013, background): “Odors with innate meaning, such as pheromones or alarm signals (Suh et al., 2004; Sachse et al., 2007; Datta et al., 2008; Root et al., 2008; Ruta et al., 2010), tend to evoke neural activity in specific “labeled lines.”
A conserved dedicated olfactory circuit for detecting harmful microbes in Drosophila. (2012, positive): “…a single class of olfactory sensory neurons (OSN), which provides input to a single glomerulus (Kurtovic et al., 2007; van der Goes van Naters and Carlson, 2007) and a sexually dimorphic and functionally segregated circuit within the olfactory system (Datta et al., 2008; Ruta et al., 2010).”
Functional analysis of a higher olfactory center, the lateral horn (2012, background): “Further, the LH appears to provide labeled lines for processing pheromones and mediating sexual behaviors (Jefferis et al., 2007; Ruta et al., 2010).”
Using translational enhancers to increase transgene expression in Drosophila (2012, methodology): “Likewise, we have constructed vectors for expressing several other proteins that have previously required multiple transgene copies to yield effective concentrations, including photoactivatable GFP (39, 40), GFP-Aequorin (41), and GCaMP3 (42).”
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster (2017, background): “PN axons project from the AL to the lateral horn (LH), which is thought to subserve stereotyped behavioral responses to odorants (Heimbeck et al., 2001; Jefferis et al., 2007; Ruta et al., 2010).”