The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex

By J. F. M. Vetencourt, Alessandro Sale, A. Viegi, L. Baroncelli, Roberto De Pasquale, Olivia F. O’Leary, Eero Castrén, L. Maffei. 2008

932 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

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Citations in the corpus

Modulation of visual responses by behavioral state in mouse visual cortex. (2010, positive): “Environmental enrichment and antidepressant therapy have been shown to increase the capacity for ocular dominance plasticity in visual cortex in adult animals (Maya Vetencourt et al., 2008; Sale et al., 2007).”
Critical periods in speech perception: new directions. (2015, background): “Other functional brakes (e.g., Lynx1, serotonin reuptake) dampen the neuromodulatory systems [e.g., acetylcholine (Ach), serotonin (5-HT)] that endogenously regulate excitatory-inhibitory (E-I) circuit balance (see sidebar) (Maya Vetencourt et al. 2008, Morishita et al. 2010).”
Serotonin and brain function: a tale of two receptors (2017, background): “Serotonin is known to play a vital role in brain development (Azmitia, 2001; Kepser and Homberg, 2015; Lambe et al., 2011) and has been found to reverse processes of maturation, both at the cellular (Kobayashi et al., 2010; Maya Vetencourt et al., 2008) and brain network level (Carhart-Harris et al.”
Removing brakes on adult brain plasticity: from molecular to behavioral interventions (2010, background): “One action of endogenous neuromodulator release such as norepinephrine, acetylcholine, serotonin, or dopamine may be to adjust a favorable E/I balance (Bear and Singer, 1986; Kasamatsu, 1991; Kilgard and Merzenich, 1998; Bao et al., 2001; Weinberger, 2007; Maya Vetencourt et al., 2008; Goard and Dan”
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “In contrast, increased BDNF signaling in the adult visual cortex induced by antidepressants or by environmental enrichment, is associated with the reappearance of critical period-like plasticity and a reduction of GABA-mediated inhibition (Maya Vetencourt et al., 2008).”
Plasticity of the visual cortex and treatment of amblyopia. (2014, positive): “Fluoxetine is a selective serotonin reuptake inhibitor whose chronic administration not only results in increased expression of BDNF and reduced levels of extracellular GABA but also re-instates LTP in response to theta burst stimulation in adult rat visual cortex [25].”
Origins of task-specific sensory-independent organization in the visual and auditory brain: neuroscience evidence, open questions and clinical implications. (2015, positive): “Treatment on the basis of this approach is being piloted for amblyopia [82,83 ,84], where endogenous permissive neuromodulators are modified to induce plasticity in adults who have had monocular visual deprivation (see”
How the Timing and Quality of Early Experiences Influence the Development of Brain Architecture (2010, positive): “A similar restoration of visual acuity can also be induced with chronic administration of fluoxetine (Maya Vetencourt et al., 2008 ).”
Hippocampal plasticity in response to exercise in schizophrenia. (2010, background): “In rodents, the beneficial effects of antidepressants on electrophysiological measures of neural plasticity related to experience are attenuated by benzodiazepines.(39) The implications of combined clozapine or other medications and exercise are unclear.”
Brain on stress: How the social environment gets under the skin (2012, result): “This finding is consistent with animal model work that shows that ocular dominance imbalance from early monocular deprivation can be reversed by patterned light exposure in adulthood that can be facilitated by fluoxetine on the one hand (116) and food restriction on the other hand (117), in which re”
A cortical circuit for gain control by behavioral state (2014, background): “…Stony Brook University, Stony Brook, NY 11790, USA 4Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94158, USA *Correspondence: yufu@phy.ucsf.edu (Y.F.), stryker@phy.ucsf.edu (M.P.S.) http://dx.doi.org/10.1016/j.cell.2014.01.050”