Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.

By A. Rybak-Wolf, Christin Stottmeister, Petar Glažar, Marvin Jens, Natalia S Pino, S. Giusti, M. Hanan, Mikaela Behm, Osnat Bartok, Reut Ashwal-Fluss and 8 more. Molecules and Cells, 2015

2,136 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2d5cc6120582eee013b4aab9138fa48d35f384f1

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Citations in the corpus

Detecting circular RNAs: bioinformatic and experimental challenges (2016, background): “Current estimates suggest that the abundance of circRNA is approximately 2–4% of the total mRNA in cells and can be much higher in some cell types, such as platelets 3,6,21,22 .”
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis (2017, methodology): “Since circ-ZNF609 is highly expressed in neural tissues (Rybak-Wolf et al., 2015), we applied an established neuronal differentiation protocol (Wichterle and Peljto, 2008), and we checked for the expression of the FLAG-tagged circZNF609 RNA by northern blot in WT cells and in the F/D clone.”
Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor (2015, background): “It should be noted, however, that another study analyzed P19 differentiated non-dividing cells and observed accumulation of circRNAs only after induction of the cells to neurons (12).”
CircRNA: functions and properties of a novel potential biomarker for cancer (2017, background): “With technological breakthroughs in high-throughput deep sequencing, large numbers of circRNAs have been recently found in human [11, 20, 40], mouse [11, 20], nematodes [11, 41], zebrafish [42], Drosophila [43], protists [44] and plants [44].”
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function (2017, methodology): “In mammals, a few hundred circRNAs are highly expressed in major brain areas, with frequently conserved expression between humans and mice (7).”
Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. (2018, background): “derived from pre-mRNAs,[10, 11, 27, 43] and circRNAs could be regulated by RNA-binding proteins [12, 43-46] post-transcriptionally, we assumed that cSMARCA5, but not mSMARCA5, was regulated by certain RNA-binding proteins post-transcriptionally in human HCC development.”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “Although the turnover of circRNAs is largely unknown 71 , it most likely involves secretion via exosomes 75 . circRNAs can interact with miRNAs, mRNAs or RNA-binding proteins (RBPs), activate or repress gene expression, or act as miRNA or protein sponges 76 SWINGN lncRNA, which is transcribed from…”
Circular RNAs: analysis, expression and potential functions (2016, methodology): “…N T Two key examples of highly expressed, neural-specific and conserved circRNAs that exhibit developmentally regulated expression are the circRNAs derived from the RIMS2 gene (circRIMS2) and the circRNA derived from the CDR1 antisense locus (ciRS-7) (Rybak-Wolf et al., 2015; Venø et al., 2015).”
Circbank: a comprehensive database for circRNA with standard nomenclature (2019, background): “CircRNAs were found to be expressed across various species including human, mouse, fly, worm, plant and yeast [3,5,28,29].”
The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “One study applied BSJ read and normal splicing junction read ratio (named circular-to-linear ratio, CLR) to represent the ratio of circRNA and linear RNA to obtain an overall expression value [93].”
Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood (2015, background): “Further, as observed in other human samples, we find that most circRNAs are derived from protein coding exonic regions or 5’ UTR sequences (Fig 1c [20],[25]).”