New insights into symptoms and neurocircuit function of anorexia nervosa
By Walter H. Kaye, Julie L. Fudge, Martin P. Paulus. Nature Reviews Neuroscience, 2009
807 citations recorded by the source corpus.
Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death. It is controversial whether such symptoms are secondary to psychosocial influences, are a consequence of obsessions and anxiety or reflect a primary disturbance of brain appetitive circuits. New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction — perhaps related to altered serotonin and dopamine metabolism — that contributes to the puzzling symptoms found in people with eating disorders. For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa.
Subfields: Clinical Psychology, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/2d3e3020dd83d40c3260656ca9edcab58993f781
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In Cognitive Neuroscience
Citations in the corpus
- The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. (2010, neutral): “Conversely, a suppressive form of hotspot dysfunction might conceivably reduce 'liking' in anorexia-type eating disorders (Kaye et al., 2009).”
- Gut feelings: the emerging biology of gut–brain communication (2011, background): “and viscerosensory dimensions of food intake, this integration is accomplished through close connections of the aINS both to a ventral circuit (including the amygdala, ACC and OFC, and the ventral striatum) and a dorsal circuit involving the dorsolateral PFC and the dorsal striatu”