CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.

By J. Burger, T. Kipps. Blood, 2006

1,233 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/2d3c643b90756a40a1d770eed9f28400d1f83732

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. L. Matrisian
2. A. Mantovani
3. F. Balkwill

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. F. Balkwill
5. J. Benovic
6. J. Busillo
7. A. Richmond
8. Li Yang

In Oncology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. F. Balkwill
5. A. Richmond
6. J. Benovic
7. J. Busillo
8. L. Matrisian

Citations in the corpus

• Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. (2007, background): “Recent reports suggest that CXCR4 may well be a key regulator of tumor invasiveness leading to local progression Cell St and tumor metastasis (Burger and Kipps, 2006).”
• Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (2008, background): “The SDF-1/CXCR4 chemokine axis mediates recruitment of several cell types, including hematopoietic progenitor cells (Burger and Kipps, 2006; Mohle et al., 1998; Peled et al., 1999; Urbich and Dimmeler, 2004).”
• Subtypes of breast cancer show preferential site of relapse. (2008, background): “Many identified genes agree with the notion that the tumor microenvironment plays an important role in distant metastasis which, together with specific attractors such as chemokines ( 35 , 36) and specific signaling pathways (e.g., WNT/h-catenin signaling and focal adhesion), are important determina”
• CXCL12/CXCR4/CXCR7 Chemokine Axis and Cancer Progression (2010, background): “reported that SCLC cells expressed high levels of functional CXCR4 receptors, and demonstrated that CXCR4 activation induced migratory and invasive responses, and adhesion to marrow stromal cells in a CXCR4- and integrin-dependent fashion [86, 87].”
• Tumor microenvironment: The role of the tumor stroma in cancer (2007, background): “The existence of this adult hemangioblast-like cell along with additional in vivo data upholds the concept that endothelial progenitor cells (EPCs) of bone marrow origin exist, circulate, and contribute to adult angiogenesis.”
• Gene expression profiling of the tumor microenvironment during breast cancer progression (2009, background): “These signaling molecules could serve as key messengers between the tumor and its microenvironment, as shown for CXCL12 and CXCL14, which are overexpressed in tumorassociated myoepithelial cells and myofibroblasts [6,7,38].”
• Regulation of CXCR4 signaling. (2007, background): “As a number of reviews have recently been published highlighting CXCR4 as a target in HIV [18–20] and its role in cancer metastasis [5,21–23], this review will focus on what is known regarding those factors that shape signaling, receptor regulation, and receptor expression, and how dysregulation of ”
• Cancer-related inflammation (2008, background): “On transformation, many cells start to express chemokine receptors and thereby use chemokines to aid in their migration to, and survival at, sites that are distant from the original tumou”