Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

By U. Römling, Michael Y. Galperin, Mark Gomelsky. Microbiology and Molecular Reviews, 2013

1,572 citations recorded by the source corpus.

Subfields: Ecology, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2d2b4f1f93348051c1c689d5224a0750f920dac9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. C. R. Lovell
2. Bernd H. A. Rehm
3. K. Gupta
4. M. Mandal
5. Hongyue Dang
6. M. Rather

In Microbiology

1. Bernd H. A. Rehm

In Molecular Biology

1. C. R. Lovell
2. Zhijian J. Chen
3. Jan Kok
4. Bernd H. A. Rehm
5. K. Gupta
6. D. van Sinderen
7. M. Mandal
8. Xin Cai

Citations in the corpus

• Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “The second group is represented by cyclic di-GMP sensing proteins which also act directly as effectors or via protein-protein interactions to mediate the output response (Römling et al., 2013).”
• Microbial Surface Colonization and Biofilm Development in Marine Environments (2015, background): “Cyclic di-GMP (c-di-GMP) is another key and ubiquitous second messenger molecule in prokaryotes, playing central roles in microbial signaling and adaptability (480).”
• The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. (2014, background): “While cyclic dinucleotides are known to mediate numerous processes in unicellular organisms such as bacteria and dictyostelia, these CDNs contain uniform 30-50 linkages (Römling et al., 2013).”
• Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action (2017, background): “bacteria can alter the biofilm formation and its dispersal in clinical environment.(236) Under stress conditions such as starvation, nitrosative conditions, etc.”
• Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. (2016, background): “During the last decade, regulation by c-di-GMP attracted much attention and was explored in great detail (Römling et al., 2013).”
• Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies (2021, background): “Bis-(3ʹ5ʹ)-cyclic dimeric guanosine monophosphate (c-di-GMP) is an intracellular signaling molecule that plays a vital role in early events of biofilm formation by restricting flagellamediated swimming motility and increasing biofilm matrix production [26].”
• Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity (2015, background): “CDNs have been studied as small-molecule second messengers synthesized by bacteria, which regulate diverse processes including motility and formation of biofilms (Römling et al., 2013).”
• Stress Physiology of Lactic Acid Bacteria (2016, background): “Several cyclic nucleotides (cyclic AMP [cAMP], cyclic GMP [cGMP], cyclic di-GMP [c-di-GMP], cyclic di-AMP [c-di-AMP], and cyclic AMP-GMP) play key roles in the regulation of bacterial cell physiology (139, 140).”