IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains.

By Marie-Paule Lefranc, C. Pommié, M. Ruiz, Véronique Giudicelli, Elodie Foulquier, L. Truong, Valérie Thouvenin-Contet, G. Lefranc. Developmental and Comparative Immunology, 2003

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IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr) is a high quality integrated information system specializing in immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complex (MHC) of human and other vertebrates. IMGT provides a common access to expertly annotated data on the genome, proteome, genetics and structure of the IG and TR, based on the IMGT Scientific chart and IMGT-ONTOLOGY. The IMGT unique numbering defined for the IG and TR variable regions and domains of all jawed vertebrates has allowed a redefinition of the limits of the framework (FR-IMGT) and complementarity determining regions (CDR-IMGT), leading, for the first time, to a standardized description of mutations, allelic polymorphisms, 2D representations (Colliers de Perles) and 3D structures, whatever the antigen receptor, the chain type, or the species. The IMGT numbering has been extended to the V-like domain and is, therefore, highly valuable for comparative analysis and evolution studies of proteins belonging to the IG superfamily.

Subfields: Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/2d02632042085e2d80b28ffddff33fe9d9a6dda0

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Citations in the corpus

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis (2008, methodology): “IMGT unique numbering (7) and on the FR-IMGT and CDR-IMGT delimitation.”
Structural Bioinformatics (positive): “The alignment of H3 loops was done according to (Chailyan et al., 2012; Lefranc et al., 2003; Morea et al., 1998) where insertions were introduced in the middle of the region comprised between the conserved residues Cys92 and Gly104.”
Modern Hopfield Networks and Attention for Immune Repertoire Classification (2020, methodology): “The motifs were implanted at positions 107, 109, and 114 according to the IMGT numbering scheme for immune receptor sequences (Lefranc et al., 2003) with probabilities 0.”
IMGT®, the international ImMunoGeneTics information system® 25 years on (2014, background): “The IMGT unique numbering has been defined for the variable V domain (V-DOMAIN of the IG and TR, and V-LIKE-DOMAIN of IgSF other than IG and TR) (47– 49), the constant C domain (C-DOMAIN of the IG and TR, and C-LIKE-DOMAIN of IgSF other than IG and TR) (50) and the groove G domain (G-DOMAIN of the…”
Five computational developability guidelines for therapeutic antibody profiling (2019, methodology): “The 137 CST and human Ig-seq sequences were IMGTnumbered (26), and IMGT CDR definitions were used to split the sequences by region.”
IMGT®, the international ImMunoGeneTics information system® (2004, background): “The IMGT unique numbering initially defined for the IG and TR domains has been extended to the V-LIKE-DOMAIN and C-LIKE-DOMAIN of IgSF proteins other than IG and TR (9,10,22).”
Antibody modeling using the Prediction of ImmunoGlobulin Structure (PIGS) web server (2014, background): “27,68), as this is the position at which the extra residues are found to be located when antibodies of known structure and different H3 loop length are superimposed.”
Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints (2016, methodology): “Following the IMGT conventions for defining the HCDR3, where the first HCDR3 residue occurs immediately following the V-gene residue Cys104 and the last HCDR3 residue occurs immediately preceding the J-gene residue Trp118, the torso is defined as the first three and the last four residues of the HCD”