Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response

By R. Silverman. Journal of Virology, 2007

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Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “This is further supported by the higher expression in CD4+ and DN cDCs of OAS1 and OAS3, which are 20,50-oligoadenylate synthetases (OAS) involved in antiviral defense (Silverman, 2007).”
The multifunctional NS1 protein of influenza A viruses. (2008, background): “These chains cause dimerization and activation of the latent RNase, RNase L, which inhibits virus replication by degradation of RNA (Silverman, 2007).”
Accessory proteins of SARS-CoV and other coronaviruses (2014, background): “A synthetase (OAS) is induced by double-stranded RNA intermediates occurring during viral replication, and leads to activation of the host’s RNase L, which in turn degrades viral and cellular mRNA (Silverman, 2007).”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “…of the upregulated genes encode enzymes that have been studied intensively and reviewed comprehensively, e.g. dsRNA-dependent protein kinase R (PKR) (Garcia et al., 2006), 2959-oligoadenylate synthetase (OAS) (Clemens, 2005; Silverman, 2007) and Mx (Martens & Howard, 2006; Haller et al., 2007).”