Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL

By C. Binder, S. Hörkkö, A. Dewan, Mi-Kyung Chang, E. Kieu, C. Goodyear, P. Shaw, W. Palinski, J. Witztum, G. Silverman. Nature Medicine, 2003

782 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/2c867d93b5a27e8f86e4c4de20f3cf23b5c6ea4d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. E. Latz
2. Katherine A. Fitzgerald
3. D. Golenbock
4. K. Moore
5. L. Stuart
6. A. Grebe
7. Christine E. Becker
8. Shizuo Akira

In Molecular Biology

1. E. Latz
2. Katherine A. Fitzgerald
3. K. Moore
4. A. Grebe
5. J. Frostegård
6. T. Kanneganti
7. J. Tschopp

Citations in the corpus

• CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation (2013, background): “In the AD brain and diabetic pancreas, amyloid plaques arise from the aggregation of pre-fibrillar amyloidogenic peptides such as the Aβ(1-42) peptide17, 18, 19 or IAPP20, 21, 22, which oligomerize and give rise to higher order structures, including fibrils.”
• Inflammation and atherosclerosis: signaling pathways and therapeutic intervention (2022, background): “Ldlr mice immunized with Streptococcus pneumoniae display an increase in the specific antibodies to oxLDL and decreased atherosclerotic lesion.(147) However, multiple clinical trials revealed that anti-infective therapies are inefficacy in mitigating atherosclerotic diseases.”
• Immunity, atherosclerosis and cardiovascular disease (2013, background): “Immunization in a mouse model with pneumococcae caused a decrease in atherosclerosis development in parallell with an increase in anti-PC levels, among other antibodies [38].”