Diverging neural pathways assemble a behavioural state from separable features in anxiety
By Sung-Yon Kim, Avishek Adhikari, Soo Yeun Lee, James H. Marshel, Christina K. Kim, Caitlin S. Mallory, Maisie Lo, Sally Pak, J. Mattis, B. Lim and 5 more. Nature, 2013
626 citations recorded by the source corpus.
Behavioural states in mammals, such as the anxious state, are characterized by several features that are coordinately regulated by diverse nervous system outputs, ranging from behavioural choice patterns to changes in physiology (in anxiety, exemplified respectively by risk-avoidance and respiratory rate alterations). Here we investigate if and how defined neural projections arising from a single coordinating brain region in mice could mediate diverse features of anxiety. Integrating behavioural assays, in vivo and in vitro electrophysiology, respiratory physiology and optogenetics, we identify a surprising new role for the bed nucleus of the stria terminalis (BNST) in the coordinated modulation of diverse anxiety features. First, two BNST subregions were unexpectedly found to exert opposite effects on the anxious state: oval BNST activity promoted several independent anxious state features, whereas anterodorsal BNST-associated activity exerted anxiolytic influence for the same features. Notably, we found that three distinct anterodorsal BNST efferent projections—to the lateral hypothalamus, parabrachial nucleus and ventral tegmental area—each implemented an independent feature of anxiolysis: reduced risk-avoidance, reduced respiratory rate, and increased positive valence, respectively. Furthermore, selective inhibition of corresponding circuit elements in freely moving mice showed opposing behavioural effects compared with excitation, and in vivo recordings during free behaviour showed native spiking patterns in anterodorsal BNST neurons that differentiated safe and anxiogenic environments. These results demonstrate that distinct BNST subregions exert opposite effects in modulating anxiety, establish separable anxiolytic roles for different anterodorsal BNST projections, and illustrate circuit mechanisms underlying selection of features for the assembly of the anxious state.
Subfields: Artificial Intelligence, Information Systems and Management, Human-Computer Interaction
View Paper: https://www.semanticscholar.org/paper/2c20c6606195ba796202d79b0a61fe23b468e40e
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In Artificial Intelligence
Citations in the corpus
- Neural Circuit Motifs in Valence Processing (2018, positive): “A more detailed dissection of the neural circuits in themouse demonstrated that distinct circuit components within the extended amygdala mediated the autonomic and behavioral components of anxiety (Kim et al., 2013).”
- Closed-loop and activity-guided optogenetic control. (2015, positive): “…projection-targeting optogenetic experiments have shown that different efferent pathways from the same anatomical structure can have very different behavioral outcomes, since they arise from distinct populations that are anatomically intermixed at the cellular level (e.g., Kim et al., 2013a).”
- Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences (2016, neutral): “…is one of the most important features that might resolve principal cell population types involved in such distinct processes (Jennings et al., 2013; Kim et al., 2013; Lammel et al., 2012; Namburi et al., 2015), but this feature has been difficult to explore in a brain-wide fashion, while remaining…”
- The ecology of human fear: survival optimization and the nervous system (2015, background): “…shown that thinking about future consequences of one’s decisions can influence current decision-making (Peters and Buchel, 2010) and it is possible that future-oriented survival encoding produces superior memory retrieval for survival-relevant information (Nairne et al., 2007; Klein et al., 2010).”