Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration.

By Quynh P. Pham, U. Sharma, A. Mikos. Biomacromolecules, 2006

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Electrospinning: applications in drug delivery and tissue engineering. (2008, background): “electrospun PCL microfibers and found that as the fiber diameter was increased, the average pore size (with values ranging from 20 to 45 mm) increased while porosity remained constant [80].”
The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. (2008, methodology): “For fibrous scaffolds, this approach has been addressed by mixing different diameter fibers [25].”
Three-Dimensional Cell Culture Matrices: State of the Art (2008, background): “fiber (*5-mmdiameter) and nano-fiber (*600-nm diameter) layers.(152) Here, by reducing fiber diameter to the nano- scale, nano-scale structural features can be achieved (Fig.”
Biomimetic materials for tissue engineering. (2008, background): “Various cells have been reported to attach, proliferate, and differentiate into or maintain their functional phenotypes on these electrospun nano-fibrous materials [48,54,58,59,61,62].”
Electrospinning: a fascinating fiber fabrication technique. (2010, methodology): “Basically, surface tension determines the upper and lower boundaries of the electrospinning window if all other variables are held constant (Fong et al., 1999; Zhang et al., 2005b; Pham et al., 2006).”