Multi-target-directed ligands to combat neurodegenerative diseases.
By A. Cavalli, Maria Laura Bolognesi, A. Minarini, M. Rosini, V. Tumiatti, M. Recanatini, C. Melchiorre. Journal of Medicinal Chemistry, 2008
1,075 citations recorded by the source corpus.
Subfields: Computational Theory and Mathematics, Organic Chemistry, Pharmacology
View Paper: https://www.semanticscholar.org/paper/2be17347074953db4e77e7b11d296b728ac23ff4
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In Computational Theory and Mathematics
In Pharmacology
Citations in the corpus
- Metals, oxidative stress and neurodegenerative disorders (2010, neutral): “Metal chelator clioquinol has been demonstrated to decrease vitamin B12 pools in brain and blood; therefore, high-dose long-term clinical trials with LA should be carefully monitored in this regard [74].”
- A perspective on multi-target drug discovery and design for complex diseases (2018, background): “Concerning neurodegenerative disorders, the polypharmacological approach looks particularly promising, given the complexity and multifactorial nature of such diseases and their unknown etiopathogenesis [17, 18].”