Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

By D. Mozaffarian, R. Micha, Sarah K. Wallace. PLoS Medicine, 2010

1,231 citations recorded by the source corpus.

Dariush Mozaffarian and colleagues conduct a systematic review and meta-analysis to investigate the effect of consuming polyunsaturated fats in place of saturated fats for lowering the risk of coronary heart disease.

Subfields: Cardiology and Cardiovascular Medicine, Nutrition and Dietetics, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/2bd29de4b58e03e9ac9b75ace9c1d94fb691f913

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. P. Calder
2. I. Graham
3. D. Mozaffarian

In Nutrition and Dietetics

1. I. Graham
2. P. Calder
3. D. Mozaffarian
4. I. Djuricić
5. M. Rogero

In Public Health, Environmental and Occupational Health

1. P. Calder
2. I. Graham
3. D. Mozaffarian
4. K. Grunert

Citations in the corpus

• Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity – A Comprehensive Review (2016, positive): “LA consumption lowers LDL-cholesterol and triglyceride-rich lipoproteins and raises HDL-cholesterol.(349) Although potential proinflammatory effects of LA have been theorized(358) and popularized, such inference is based largely on rodent experiments, with little supportive evidence in humans.”
• 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. (2016, background): “In order to get an overall estimate of the impact of dietary modifications on the CV risk, different meta-analyses have been performed, sometimes with inconsistent outcomes.(135,136) This is due not only to methodological problems, particularly inadequate sample size or the short duration of many tr”
• Viewpoint: Regulating meat consumption to improve health, the environment and animal welfare (2020, background): “…meat consumption is characterized by a high content of cholesterol and saturated fatty acids, which are both associated with coronary heart disease (Mozaffarian et al., 2010) and diabetes (Micha et al., 2010; Wolk, 2017).4 Moreover, all meat intake is positively associated with weight gain…”