A Brief Review on the Mechanisms of miRNA Regulation

By Yimei Cai, Xiaomin Yu, Songnian Hu, Jun Yu. Genomics, Proteomics & Bioinformatics, 2009

923 citations recorded by the source corpus.

MicroRNAs (miRNAs) are a class of short, endogenously-initiated non-coding RNAs that post-transcriptionally control gene expression via either translational repression or mRNA degradation. It is becoming evident that miRNAs are playing significant roles in regulatory mechanisms operating in various organisms, including developmental timing and host-pathogen interactions as well as cell differentiation, proliferation, apoptosis and tumorigenesis. Likewise, as a regulatory element, miRNA itself is coordinatively modulated by multifarious effectors when carrying out basic functions, such as SNP, miRNA editing, methylation and circadian clock. This mini-review summarized the current understanding of interactions between miRNAs and their targets, including recent advancements in deciphering the regulatory mechanisms that control the biogenesis and functionality of miRNAs in various cellular processes.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2ba9f85cee174c5383c255a946c35202d0f7e8f9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Serena Liu
2. Cole Trapnell
3. Giulia Fiscon
4. Manel Esteller
5. Paola Paci
6. V. Licursi
7. Federica Conte

In Molecular Biology

1. M. Kulis
2. Serena Liu
3. Cole Trapnell
4. Giulia Fiscon
5. Manel Esteller
6. Paola Paci
7. V. Licursi
8. Federica Conte

Citations in the corpus

• MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis (2019, background): “National Research Council, Via dei Taurini 19, 00185 Rome, Italy Full list of author information is available at the end of the article organisms, including developmental timing, cell differentiation, proliferation, apoptosis as well as tumorigenesis [4, 5].”
• Single-cell transcriptome sequencing: recent advances and remaining challenges (2016, methodology): “Consequently, current methods are ill suited to investigate non-polyadenylated transcript classes, such as regulatory non-coding RNA (e.g. microRNAs 46,47 , lncRNAs 48 , or circular RNAs 49,50 ) or bacterial RNA 21 .”
• Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth (2012, neutral): “They play significant roles in many regulatory mechanisms such as developmental timing and host-pathogen interactions as well as cell differentiation, proliferation, apoptosis, and tumorigenesis in various organisms [16, 17].”
• DNA methylation and cancer. (2010, background): “miRNAs are short, 20- to 30-nucleotide-long, regulatory RNAs (Cai et al., 2009).”